CELSR2

cadherin EGF LAG seven-pass G-type receptor 2

Ensembl:
ENSG00000143126
UniProt:
Q9HCU4
OMIM:
604265
Synonyms:
ADGRC2, CDHF10, EGFL2, FLAMINGO1, KIAA0279

Cilia effects upon perturbation of CELSR2

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.30) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Joubert Syndrome

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Has been shown to be required for ciliogenesis ( 27894351). Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus ( 29420175), Whereas i ctivation of Celsr2, Celsr3, Fzd3, and Vangl2 perturbs the organization of ependymal multicilia at the single-cell level ( 25024228). Compared to wild–type mice, the number of cilia and ciliary tufts was clearly reduced in Celsr2−/− mice (20473291).

Model organism evidence

Mus musculus (2 references)

Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis.

During the past decade, evidence has accumulated for a key role of CELSR1 in epithelial planar cell polarity (PCP), and for CELSR2 and CELSR3 in ciliogenesis and neural development, especially neuron migration and axon guidance in the central, peripheral and enteric nervous systems.

PMIDs: 36712970, 28716607

Drosophila (3 references)

Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis.

Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia.

PMIDs: 36712970, 31115335, 28052552