CELSR3

cadherin EGF LAG seven-pass G-type receptor 3

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000008300
UniProt:
Q9NYQ7
OMIM:
604264
Synonyms:
ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.78) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:29420175, PMID:25024228

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus ( 29420175), controls the function of ependymal cilia ( 29327175), Whereas i ctivation of Celsr2, Celsr3, Fzd3, and Vangl2 perturbs the organization of ependymal multicilia at the single-cell level ( 25024228).