CEP112

centrosomal protein 112

Ensembl:
ENSG00000154240
UniProt:
Q8N8E3
OMIM:
618980
Synonyms:
CCDC46, MGC33887

Cilia effects upon perturbation of CEP112

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.87) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased lean body mass, decreased total body fat amount

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CEP112 positioned radially close to the basal body center, with a second population at the daughter centriole, and axially in the same region of other basal foot proteins (33038334).