CEP126

Cilia effects upon perturbation of CEP126

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

impaired pupillary reflex, increased fasting circulating glucose level

Mouse ciliopathy phenotype:

male infertility

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

Cep126 localised to the centrosome in a microtubule-independent manner and CEP126 is a regulator of microtubule organisation at the centrosome that acts through modulation of the transport of pericentriolar satellites, and consequently, of the organisation of cell structure(24867236).