CEP131

centrosomal protein 131

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000141577
UniProt:: Q9UPN4
OMIM:: 613479
Synonyms:: AZ1, AZI1, KIAA1118

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, centrosome, cytosol, cilia

References: PMID:27224062, PMID:41005307, PMID:19254375, PMID:30695697

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Protein processing & maturation
Cell migration & adhesion
Transition zone

Function

Contributor to ciliogenesis in certain tissues in the developing vertebrate embryo, involved in assembling the cilium and in determination of the length of the axoneme (19254375). The Atoh1- Cep131-CS integrity axis would act as a gatekeeper during GNPs’ ciliogenesis, as it would provide cells an essential machinery (i.e., the CS) for building the primary cilia (PMID: 30695697).

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