CEP152

centrosomal protein 152

Ensembl:
ENSG00000103995
UniProt:
O94986
OMIM:
613529
Synonyms:
KIAA0912, MCPH9, SCKL5

Cilia effects upon perturbation of CEP152

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Microcephaly

Subcellular localization

basal body, centrosome, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication(18854586) . Cep152 interacts with Plk4 and is required for centriole duplication(21059850).

Model organism evidence

Drosophila (1 reference)

Lastly, we show that Asl is required for proper basal body function and spermatid axoneme formation.

PMIDs: 27185836