CEP152

centrosomal protein 152

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000103995
UniProt:: O94986
OMIM:: 613529
Synonyms:: KIAA0912, MCPH9, SCKL5

Cilia effects upon perturbation of CEP152

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Microcephaly

References: PMID:21983783, PMID:20598275

Subcellular localization

basal body, centrosome, cytosol, nucleus

References: PMID:41005307, PMID:18854586, PMID:21059850

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Protein processing & maturation

Function

Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication(18854586) . Cep152 interacts with Plk4 and is required for centriole duplication(21059850).

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