CEP170

centrosomal protein 170

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000276725
UniProt:: Q5SW79
OMIM:: 613023
Synonyms:: FAM68A, KAB, KIAA0470

Cilia effects upon perturbation of CEP170

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.26) PMID:41160700

Subcellular localization

basal body, centrosome, nucleus

References: PMID:41005307, PMID:31197141

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Required for anchoring the subdistal appendages (SDA) complex in the centrifuge to the cytoplasmic microtubule network. It is an FHDC1 buinding protein to keep this connection (29742020). Recruits microtubule-depolymerizing factor KIF2A to disassemble cilium (31197141).

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