CEP192

centrosomal protein 192

Ensembl:
ENSG00000101639
UniProt:
Q8TEP8
OMIM:
616426
Synonyms:
FLJ10352, KIAA1569, PPP1R62

Cilia effects upon perturbation of CEP192

Cilia number / % ciliated:
No effect

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=0.74) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Plk4 clearly colocalized with Cep192 or Cep152, albeit with only a small fraction of their sig ls . Cep192 and Cep152 competitively interacted with the cryptic polo box of Plk4 through their homologous N-termi l sequences containing acidic-δΌͺ-helix and N/Q-rich motifs(24277814).

Model organism evidence

C. elegans (1 reference)

Super-resolution imaging revealed that this PCM inserts inside the lumen of the ciliary axoneme and directly nucleates the assembly of dendritic microtubules toward the cell body.

PMIDs: 33798428

Mus musculus (1 reference)

Centrioles are key structural elements of centrosomes and primary cilia.

PMIDs: 22349705

Danio rerio (1 reference)

Centrioles are key structural elements of centrosomes and primary cilia.

PMIDs: 22349705