CEP192

centrosomal protein 192

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000101639
UniProt:: Q8TEP8
OMIM:: 616426
Synonyms:: FLJ10352, KIAA1569, PPP1R62

Cilia effects upon perturbation of CEP192

Cilia number / % ciliated:: No effect

Ciliogenesis screen results (3 screens)

Kim2016: Not Reported
Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=0.74) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol

References: PMID:41005307, PMID:24277814

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Protein processing & maturation

Function

Plk4 clearly colocalized with Cep192 or Cep152, albeit with only a small fraction of their signals . Cep192 and Cep152 competitively interacted with the cryptic polo box of Plk4 through their homologous N-terminal sequences containing acidic-α-helix and N/Q-rich motifs(24277814).

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