CEP20

centrosomal protein 20

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000276914
UniProt:: Q96NB1
OMIM:: 617149
Synonyms:: C16ORF63, DKFZP686N1651, FLJ31153, FOPNL, FOR20, PHSECRG2

Cilia effects upon perturbation of CEP20

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Subcellular localization

basal body

References: PMID:41005307, PMID:26643951, PMID:28694353

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cilia length regulation

Function

Regulation of integrity of the centriole distal end and membrane anchoring. Complex with OFD1 to initiate ciliogenesis and control cilia length (26643951). Involved in cilia formation and regulating the interaction of PCM1 satellites with and motors (20551181). Regulates the assembly and maintains the stability and dynamics of . It may inhibit tubulin assembly by sequestering soluble tubulin (28694353).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.