CEP57

centrosomal protein 57

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000166037
UniProt:: Q86XR8
OMIM:: 607951
Synonyms:: KIAA0092, TRANSLOKIN, TSP57

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.29) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Short-Rib Thoracic Dysplasia

References: PMID:31943948

Subcellular localization

centriolar satellites, centrosome, cytosol

References: PMID:35207567

Functional category

Metabolism; Motile cilium & axoneme; Ciliary assembly/disassembly; Cilia–cytoskeleton/adhesion links

Function

The centrosome protein Cep57, which is localized to the central spindle and midbody, acts as a spindle organizer and is required for cytokinesis. Depletion of Cep57 disrupted microtubule assembly of the central spindle and further led to abnormal midbody localization of MKLP1, Plk1, and Aurora B, which resulted in cytokinesis failure and the formation of binuclear cells. Furthermore, we found that Cep57 directly recruited Tektin 1 to the midbody matrix to regulate microtubule organization. Thus, our data reveal that Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody(PMID: 23569207).

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