CEP63

centrosomal protein 63

Ensembl:
ENSG00000182923
UniProt:
Q96MT8
OMIM:
614724
Synonyms:
FLJ13386

Cilia effects upon perturbation of CEP63

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.19) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal vocalization, decreased total reti thickness, abnormal reti inner nuclear layer morphology, abnormal reti outer nuclear layer morphology

Subcellular localization

basal body, centrosome, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

The Cep63 co-localized with Cep152 and associated laterally with scent centrioles(24240477).