CEP68

Cilia effects upon perturbation of CEP68

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.54) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased leukocyte cell number

Mouse ciliopathy phenotype:

male infertility, increased heart weight

Subcellular localization

basal body, centrosome

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

Connection of the two centrosomes of a cell during interphase, required for cilia and mitotic spingle formation. Rootletin binds CEP68 modulating the thickness of rootletin filaments and promoting rootletin filament formation. Rootletin and CEP68 rings are the anchoring point of filaments that radiate into the cytoplasm (29463719). CEP68, C- P1 and Rootletin, cooperate in centrosome cohesion (18042621). Interacts with CEP215 to retain it on the peripheral pericentriolar material, inhibiting centriole separation following disengagement (25503564)