CEP70

centrosomal protein 70

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000114107
UniProt:
Q8NHQ1
OMIM:
614310
Synonyms:
BITE, FLJ13036

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.63) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, centrosome, cytosol, nucleus, cilia

References: PMID:41005307, PMID:25342559

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin chain from centrosomal protein of 70 kDa (Cep70), a requirement for Cep70 to interact with γ-tubulin and localize at the centrosome(25342559).