CEP85

centrosomal protein 85

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000130695
UniProt:: Q6P2H3
OMIM:: 618898
Synonyms:: CCDC21, DKFZP434L0117

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.29) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, centrosome, nucleus

References: PMID:26220856

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Cep85 is a bo fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1γ (also known as PPP1CC) to antagonize Nek2A activity in order to maintain the centrosome integrity in interphase in mammalian cells (26220856).

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