CEP85L

centrosomal protein 85 like

Ensembl:
ENSG00000111860
UniProt:
Q5SZL2
OMIM:
618865
Synonyms:
BA57K17.2, C6ORF204, NY-BR-15

Cilia effects upon perturbation of CEP85L

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=530, lfc=-0.90) PMID:30270045

Phenotypes

Mouse phenotype:
decreased prepulse inhibition, decreased thigmotaxis, abnormal lymph node morphology, decreased anxiety-related response, enlarged lymph nodes, abnormal skin morphology, decreased startle reflex, abnormal behavior, abnormal startle reflex
Mouse ciliopathy phenotype:
enlarged kidney, abnormal auditory brainstem response, abnormal kidney morphology

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly

Function

C6ORF204 localized to centrosome().