CETN1

centrin 1

Ensembl:
ENSG00000177143
UniProt:
Q12798
OMIM:
603187
Synonyms:
CEN1, CETN

Cilia effects upon perturbation of CETN1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

CEP290 and CETN1 similarly overlap at the wildtype connecting cilium and CETN1 accumulation in the Cetn2,Cetn3 central connecting cilium (30647131).

Model organism evidence

Mus musculus (2 references)

Primary Cilia in Amacrine Cells in Retinal Development.

Centrins (CETN1-4) are ubiquitous and conserved EF-hand-family Ca2+-binding proteins associated with the centrosome, basal body, and transition zone.

PMIDs: 34241625, 30647131