CETN2

centrin 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000147400
UniProt:
P41208
OMIM:
300006
Synonyms:
CALT, CEN2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=441, lfc=0.91) PMID:30270045

Ciliopathy associations

  • Hydrocephalus

References: PMID:24790208

Subcellular localization

basal body, centrosome, cytosol, flagella, nucleus

References: Human Protein Atlas, PMID:12176356, PMID:25753040, PMID:30647131

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

Synthesis and accumulation of CETN2 is required for centriole duplication (12176356). Regulation of primary ciliogenesis through controlling CP110 levels and localisation (25753040). Stabilisation of connecting cilium axoneme structure. CETN2 is required for photoreceptor survival by regulating SPATA7 CC localization, distal connecting cilium/axoneme microtubule stability, and outer segment disc orientation (30647131)