CETN2

centrin 2

Ensembl:
ENSG00000147400, ENSG00000292191
UniProt:
P41208
OMIM:
300006
Synonyms:
CALT, CEN2

Cilia effects upon perturbation of CETN2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=441, lfc=0.91) PMID:30270045

Ciliopathy associations

  • Hydrocephalus

Subcellular localization

basal body, centrosome, cytosol, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

Synthesis and accumulation of CETN2 is required for centriole duplication (12176356). Regulation of primary ciliogenesis through controlling CP110 levels and localisation (25753040). Stabilisation of connecting cilium axoneme structure. CETN2 is required for photoreceptor survival by regulating SPATA7 CC localization, distal connecting cilium/axoneme microtubule stability, and outer segment disc orientation (30647131)

Model organism evidence

Mus musculus (3 references)

Primary Cilia in Amacrine Cells in Retinal Development.

Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).

PMIDs: 34241625, 30647131, 27328943

Xenopus (1 reference)

Centrins (Cetns) are highly conserved, widely expressed, and multifunctional Ca(2+)-binding eukaryotic signature proteins best known for their roles in ciliogenesis and as critical components of the global genome nucleotide excision repair system.

PMIDs: 26014913