CETN3

centrin 3

Ensembl:
ENSG00000153140
UniProt:
O15182
OMIM:
602907
Synonyms:
CEN3

Cilia effects upon perturbation of CETN3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.83) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=156, lfc=0.80) PMID:30270045

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

CETN3 is also required for photoreceptor survival by regulating SPATA7 CC localization, distal connecting cilium/axoneme microtubule stability, and outer segment disc orientation (30647131). CETN3 restrains centriole assembly by inhibiting Mps1 ki se activity at centrosomes and phosphorylation of both the specific substrate CETN2 (26354417)

Model organism evidence

Mus musculus (2 references)

Cilia are hair-like projections of the plasma membrane with an inner microtubule skeleton known as axoneme.

Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).

PMIDs: 36611937, 30647131

Danio rerio (1 reference)

Cilia are hair-like projections of the plasma membrane with an inner microtubule skeleton known as axoneme.

PMIDs: 36611937

Xenopus (1 reference)

Centrins (Cetns) are highly conserved, widely expressed, and multifunctional Ca(2+)-binding eukaryotic signature proteins best known for their roles in ciliogenesis and as critical components of the global genome nucleotide excision repair system.

PMIDs: 26014913