CETN3

centrin 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000153140
UniProt:
O15182
OMIM:
602907
Synonyms:
CEN3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.83) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=156, lfc=0.80) PMID:30270045

Subcellular localization

basal body, centrosome

References: PMID:41005307, PMID:30647131, PMID:26354417

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

CETN3 is also required for photoreceptor survival by regulating SPATA7 CC localization, distal connecting cilium/axoneme microtubule stability, and outer segment disc orientation (30647131). CETN3 restrains centriole assembly by inhibiting Mps1 kinase activity at centrosomes and phosphorylation of both the specific substrate CETN2 (26354417)