CFAP100
cilia and flagella associated protein 100
- Ensembl:
- ENSG00000163885
- UniProt:
- Q494V2
- Synonyms:
- CCDC37, FLJ40083, MIA1
Cilia effects upon perturbation of CFAP100
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Cell migration & adhesion
Function
Also called CCDC37 or MIA1. Formation of the modifier of inner arms (MIA) complex in flagella, which is required for normal ciliary motility. MIA1 affects the structure and stablity of I1 dynein (23569216)
Model organism evidence
Mus musculus (2 references)
Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division.
This activity was mediated by the pore-forming exotoxin alveolysin, which increased the production of the membrane-anchored protein CD59 and of cilia- and flagella-associated prot