CFAP126

cilia and flagella associated protein 126

Ensembl:: ENSG00000188931
UniProt:: Q5VTH2
OMIM:: 616119
Synonyms:: C1ORF192, FLATTOP, FLTP

Cilia effects upon perturbation of CFAP126

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=98, lfc=-1.32) PMID:30270045

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

Also called Flattop.Required cilia formation. Regulator for BB docking and positioning in mono- and multiciliated cell types that acquire pla r cell polarity. Fltp interacts with Dlg3 to surround the basal body and anchor this organelle asymmetrically to the apical cortex (25296022)

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