CFAP157

cilia and flagella associated protein 157

Ensembl:: ENSG00000160401
UniProt:: Q5JU67
Synonyms:: C9ORF117

Cilia effects upon perturbation of CFAP157

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

Interacts with tubulin and CEP350, it targets proteins to the centrosome and is therefore required for ciliogenesis. Downstream efector of FOXJ1 that acts during spermiogenesis potentially suppressing the formation of supernumerary axonemes and ensures a correct ultrastructur (27965440)

Model organism evidence

Mus musculus (1 reference)

CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility.

PMIDs: 27965440

Xenopus (1 reference)

CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility.

PMIDs: 27965440

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