CFAP157

cilia and flagella associated protein 157

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000160401
UniProt:
Q5JU67
Synonyms:
C9ORF117

Ciliogenesis screen results (1 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

References: PMID:41410385, PMID:42010243, PMID:27965440

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Interacts with tubulin and CEP350, it targets proteins to the centrosome and is therefore required for ciliogenesis. Downstream efector of FOXJ1 that acts during spermiogenesis potentially suppressing the formation of supernumerary axonemes and ensures a correct ultrastructur (27965440)