CFAP161

cilia and flagella associated protein 161

Ensembl:
ENSG00000156206
UniProt:
Q6P656
Synonyms:
C15ORF26, FLJ38615

Cilia effects upon perturbation of CFAP161

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased total body fat amount, enlarged spleen, abnormal thyroid gland morphology, abnormal mouth morphology, abnormal spleen morphology, abnormal mammary gland morphology, enlarged thyroid gland

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Also called C15orf26. Studies in zebrafish suggest it is essential for cilia motility (24094744)

Model organism evidence

Mus musculus (1 reference)

The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.

PMIDs: 34172766

Xenopus (1 reference)

The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.

PMIDs: 34172766