CFAP20
cilia and flagella associated protein 20
- Ensembl:
- ENSG00000070761
- UniProt:
- Q9Y6A4
- OMIM:
- 617906
- Synonyms:
- CFAP20, CFAP20, ENSG00000070761, GTL3, BUG22
Cilia effects upon perturbation of CFAP20
- Loss-of-function effect:
- Longer cilia
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Subcellular localization
basal body, cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Cell migration & adhesion
Function
High-speed video microscopy and morphological analysis of Bug22p-depleted cells showed that the protein plays an important role in the efficiency of ciliary movement by participating in the stroke shape and rigidity of cilia(PMID: 20118210).
Model organism evidence
C. elegans (1 reference)
Modulation of inner junction proteins contributes to axoneme differentiation.
PMIDs: 37463209
Mus musculus (1 reference)
We show here that BROMI interacts not only with CCRK but also with CFAP20, an evolutionarily conserved ciliary protein, and with FAM149B1/ Joubert syndrome (JBTS)36, a protein in which mutations cause JBTS.
PMIDs: 35609210