CFAP20

cilia and flagella associated protein 20

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000070761
UniProt:: Q9Y6A4
OMIM:: 617906
Synonyms:: ENSG00000070761, GTL3, BUG22, EVORF, fSAP23, C16orf80

Cilia effects upon perturbation of CFAP20

Loss-of-function effect:: Longer cilia

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia

References: PMID:20118210

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

High-speed video microscopy and morphological analysis of Bug22p-depleted cells showed that the protein plays an important role in the efficiency of ciliary movement by participating in the stroke shape and rigidity of cilia(PMID: 20118210).

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