CFAP206

cilia and flagella associated protein 206

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000272514
UniProt:: Q8IYR0
Synonyms:: C6ORF165, DJ382I10.1, FLJ25974

Cilia effects upon perturbation of CFAP206

Cilia number / % ciliated:: No effect
Loss-of-function effect:: No effect

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: no spontaneous movement

Ciliopathy associations

Male Infertility

References: PMID:32376681, PMID:35207567, PMID:34255152

Subcellular localization

basal body, cilia

References: PMID:42010243, PMID:25139857, PMID:32376681, PMID:39743588

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

CFAP206 localises to the ciliary axoneme and basal body. The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development(32376681). Identified by cryo-EM as a component of radial spokes 1 and 2 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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