CFAP206

cilia and flagella associated protein 206

Ensembl:
ENSG00000272514
UniProt:
Q8IYR0
Synonyms:
C6ORF165, DJ382I10.1, FLJ25974

Cilia effects upon perturbation of CFAP206

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
no spontaneous movement
Mouse ciliopathy phenotype:
male infertility, cataract, female infertility

Ciliopathy associations

  • Male Infertility

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CFAP206 localises to the ciliary axoneme and basal body. The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development(32376681).

Model organism evidence

Mus musculus (1 reference)

Here, we report on the FOXJ1 target gene Cfap206, orthologues of which so far have only been studied in Chlamydomonas and Tetrahymena In mouse and Xenopus, Cfap206 was co-expressed with and dependent on Foxj1 CFAP206 protein localised to the basal body and to the axoneme of motile cilia.

PMIDs: 32376681

Xenopus (1 reference)

Here, we report on the FOXJ1 target gene Cfap206, orthologues of which so far have only been studied in Chlamydomonas and Tetrahymena In mouse and Xenopus, Cfap206 was co-expressed with and dependent on Foxj1 CFAP206 protein localised to the basal body and to the axoneme of motile cilia.

PMIDs: 32376681