CFAP44

cilia and flagella associated protein 44

Ensembl:: ENSG00000206530
UniProt:: Q96MT7
OMIM:: 617559
Synonyms:: FLJ11142, WDR52

Cilia effects upon perturbation of CFAP44

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased circulating serum albumin level
Mouse ciliopathy phenotype:: male infertility

Ciliopathy associations

Male Infertility

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating(29687140).

Model organism evidence

Xenopus (1 reference)

In particular, we show that the inner dynein arm tether Cfap44 is an RNA-associated protein that localizes not only to axonemes, but also to liquid-like organelles in the cytoplasm called DynAPs.

PMIDs: 32898505

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