CFAP61

cilia and flagella associated protein 61

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000089101
UniProt:: Q8NHU2
OMIM:: 620381
Synonyms:: C20ORF26, CAM-IP3, DJ1002M8.3, DKFZP434K156

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased bone mineral content, increased blood urea nitrogen level

Ciliopathy associations

Male Infertility

References: PMID:34792097, PMID:35387802

Subcellular localization

cilia

References: PMID:25694453, PMID:36659204

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

CFAP61 recognized in human sperm flagellum with a strong accumulation signal at the midpiece as well as throughout the flagellum, and also noted that co-localizes with tubulin, also suggesting axonemal pattern for CFAP61(36659204).

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