CFAP69

cilia and flagella associated protein 69

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000105792
UniProt:: A5D8W1
OMIM:: 617949
Synonyms:: C7ORF63, FAP69, FLJ21062

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance, hyperactivity

Subcellular localization

flagella

References: PMID:29606301, PMID:28495971

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

CFAP69 is necessary for flagellum assembly/stability. Mutations cause multiple morphological abnormalities of the flagella and primary male infertility (29606301). Regulates olfactory transduction kinetics in the olfactory sensory neurons of mice (28495971)

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