CFAP70

cilia and flagella associated protein 70

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000156042
UniProt:
Q5T0N1
OMIM:
618661
Synonyms:
FLJ25765, TTC18

Cilia effects upon perturbation of CFAP70

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (1 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Male Infertility

References: PMID:31621862

Subcellular localization

cilia, axoneme, central apparatus, basal body

References: doi:10.7554/eLife.110601, PMID:41410385, PMID:41005307, PMID:30158508

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Regulator component of the outer dynein arm in motile cilia and flagella, regulating ciliary motility and length (30158508) Localizes to the axonemal central lumen as part of the C2a projection of the motile-cilia central apparatus; knockout destabilizes the C2a projection and central-pair microtubules (Lyu et al. 2026, eLife, DOI 10.7554/eLife.110601).