CFAP70

cilia and flagella associated protein 70

Ensembl:
ENSG00000156042
UniProt:
Q5T0N1
OMIM:
618661
Synonyms:
FLJ25765, TTC18

Cilia effects upon perturbation of CFAP70

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Male Infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Regulator component of the outer dynein arm in motile cilia and flagella, regulating ciliary motility and length (30158508)

Model organism evidence

Mus musculus (1 reference)

Experimental and molecular support for Cfap70 as a causative gene of 'multiple morphological abnormalities of the flagella' with male infertility†.

PMIDs: 37458246