CFAP77

cilia and flagella associated protein 77

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000188523
UniProt:
Q6ZQR2
Synonyms:
C9ORF171, FLJ46082

Ciliogenesis screen results (1 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:42010243, PMID:37061538

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CFAP77A and CFAP77B proteins expressed as fusions with C-terminal 3HA tag under the control of respective tive promoters revealed that CFAP77A is present at the proximal end of the cilium while CFAP77B localizes along the entire cilium length except for the distal tip (37061538).