CFH

complement factor H

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000000971
UniProt:: P08603
OMIM:: 134370
Synonyms:: ARMD4, ARMS1, FHL1, HF, HF1, HF2, HUS

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:41604455, PMID:33859044

Functional category

Ciliary assembly/disassembly

Function

C. elegans CFH homolog localizes on CEP mechanosensory neuron cilia where it has noncanonical roles in maintaining inversin/NPHP-2 within its mesake proximal compartment and preventing inversin/NPHP-2 accumulation in distal cilia compartments in aging adults(33859044).

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