CFH

complement factor H

Ensembl:
ENSG00000000971
UniProt:
P08603
OMIM:
134370
Synonyms:
ARMD4, ARMS1, FHL1, HF, HF1

Cilia effects upon perturbation of CFH

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

C. elegans CFH homolog localizes on CEP mechanosensory neuron cilia where it has noncanonical roles in maintaining inversin/NPHP-2 within its mesake proximal compartment and preventing inversin/NPHP-2 accumulation in distal cilia compartments in aging adults(33859044).

Model organism evidence

C. elegans (1 reference)

Here, we investigate the consequences of CFH and CFH-1 loss-of-function mutations on the dynamics and localization of intraflagellar transport (IFT) train and visual cycle components in these cells.

PMIDs: 41278837