CHEK2

checkpoint kinase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000183765
OMIM:
604373
Synonyms:
BA444G7, CDS1, CHK2, HUCDS1, PP1425, RAD53

Subcellular localization

cilia, Nucleoplasm, Golgi apparatus

References: PMID:40796227

Functional category

  • Metabolism
  • Non-motile cilium / primary cilium

Function

Results showed that RAD51 localized predominantly at the base of the cilium, while ATR, PARP1, CHK1, and CHK2 were also detected within the ciliary shaft. Additionally, ATR, PARP1, CHK1 and CHK2 exhibited colocalization within the ciliary structure (Figure 1A). This suggests a spatial association between these DDR proteins and the cholangiocyte primary cilium, consistent with a potential functional interplay in DNA repair processes.