CHFR

Cilia effects upon perturbation of CHFR

Ciliogenesis screen results (6 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.43) PMID:20393562
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.25) PMID:41160700

Phenotypes

Mouse phenotype:

thin ventricular wall, abnormal skin coloration, abnormal skin morphology, decreased heart rate, abnormal inspiratory capacity, increased lung compliance, abnormal coat/hair pigmentation, decreased lung elastance, abnormal spleen morphology

Mouse ciliopathy phenotype:

increased liver weight, increased circulating aspartate transamise level, small testis, abnormal testis morphology, increased kidney weight, increased circulating alanine transamise level

Subcellular localization

basal body, cilia, microtubules, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

The tumor suppressor protein, CHFR, localizes to the base of OSE primary cilia(23351307).