CHRM3

cholinergic receptor muscarinic 3

Ensembl:
ENSG00000133019
UniProt:
P20309
OMIM:
118494
Synonyms:
M3ACHR

Cilia effects upon perturbation of CHRM3

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.40) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
Megacystis

Subcellular localization

cilia, endosome

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Cilia length regulation

Function

CHRM3 was localized to primary cilia of endothelial and cerebrovascular cells, and that CHRM3 expression was downregulated in cilialess cells. CHRM3 activation enhanced cilia length and sensory function in terms of eNOS activation (39885271).