CHRNA3

cholinergic receptor nicotinic alpha 3 subunit

Ensembl:
ENSG00000080644
UniProt:
P32297
OMIM:
118503

Cilia effects upon perturbation of CHRNA3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-13.36) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.30) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
congenital anomaly of kidney and urinary tract

Subcellular localization

basal body, cilia, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Transition zone

Function

CHR3 has localized in ciliary tip, basal body ,transition zone.