CIBAR1P1

CIBAR1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32278]family with sequence similarity 92 member A

Ensembl:: ENSG00000157021
Synonyms:: FAM92A1P1, FAM92A2

Cilia effects upon perturbation of CIBAR1P1

Cilia number / % ciliated:: Decrease
Loss-of-function effect:: Decrease

Subcellular localization

basal body, transition zone, centriole

Functional category

Motile cilium & axoneme
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Ciliary assembly/disassembly

Function

FAM92A (CIBAR1) harbors lipid-binding BAR domains and interacts with Cby1 (Chibby1) at centrioles/basal bodies. Knockdown in RPE1 cells impairs ciliogenesis. Together with Cby1, promotes ciliogenesis via regulation of membrane-remodeling processes involving Rab8. Part of the transition zone module. Associated with Postaxial Polydactyly type A9 (PAPA9) (PMID:27528616, 30395363, 41641302). FAM92A (CIBAR1) knockdown in RPE1 cells impairs ciliogenesis. Interacts with Cby1 at centrioles/basal bodies; promotes ciliogenesis via membrane remodeling involving Rab8. ciBAR1/FAM92A KO mice show reduced cilia number and length in pancreas and MEFs.

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