CIBAR2
CBY1 interacting BAR domain containing 2
- Ensembl:
- ENSG00000153789
- UniProt:
- Q6ZTR7
- OMIM:
- 617274
- Synonyms:
- FAM92B, FLJ44299
Cilia effects upon perturbation of CIBAR2
Subcellular localization
basal body, cilia
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Transition zone
Function
Cby1-interacting partner to promote ciliogenesis through regulation of membrane- remodeling processes, inducing the formation of membrane tubule like structures, which contain Rab8 (27528616).
Model organism evidence
Mus musculus (1 reference)
These findings elucidate the structural basis of FAM92A's membrane remodeling and CBY1 interaction, providing a molecular framework for its function in ciliogenesis and suggesting broader implications for FAM92 family proteins.
PMIDs: 40484380
Drosophila (3 references)
Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation.
Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding.