CIMAP2

Subcellular localization

motile cilia, flagella

References: PMID:37327785, PMID:39743588

Functional category

• Non-motile cilium / primary cilium
• Cilia–cytoskeleton/adhesion links

Function

Our structures further show that ciliary microtubule-associated proteins (CIMAPs) are ubiquitous features of mammalian axonemes but have cilium-specific distribution (Extended Data Fig. 3a,b). For example, CIMAP3 is present in all mammalian axonemes hitherto studied, yet CIMAP2, which binds the same protofilament cleft, is found only in sperm (Extended Data Fig. 3b)(37327785). Another pair of axonemal MAPs, CIMAP2 (LEXM) and CIMAP3 (Pitchfork), occupy the inter-protofilament cleft between protofilaments A03/A04 in a manner similar to CIMAP1. However, these proteins repeat alternately along the DMT, resulting in an overall periodicity of 96 nm (Fig. S6B)(37327785). CIMIP2 (likely CIMIP2 family member) — CIMIP2 proteins are associated with the inner region of axonemal doublet microtubules, suggesting a role as microtubule inner proteins in motile cilia and flagella(37327785).