CIMAP3

ciliary microtubule associated protein 3

Ensembl:: ENSG00000173947
UniProt:: Q8TCI5
OMIM:: 614234
Synonyms:: C1ORF88, FLJ23853, PIFO, PITCHFORK

Cilia effects upon perturbation of CIMAP3

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

Controls cilia retraction as well as the liberation and duplication of the basal body/centrosome during primary cilia disassembly. Enhances AurA Activation and regulates left-right asymmetry. Mutations cause cilia retraction, basal body detachment and overreplication defects (20643351). Critical component of the Smo ciliary targeting complex and Hh pathway activation (26901434).

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