CIP2A
cellular inhibitor of PP2A
- Ensembl:
- ENSG00000163507
- UniProt:
- Q8TCG1
- OMIM:
- 610643
- Synonyms:
- KIAA1524
Cilia effects upon perturbation of CIP2A
- Cilia number / % ciliated:
- Incrased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Shorter cilia
Subcellular localization
basal body, cilia, transition zone
Functional category
- Ciliary assembly/disassembly
- Transition zone
- Cilia length regulation
Function
Promotes primary cilia disassembly through the activation of Aurora A ki se. Depletion increases ciliated cells and cilia length in reti l pigment epithelium cells. CIP2A enhances NEK2 ki se activity to facilitate centrosome separation. It plays a role in c-MYC stabilization and metabolic reprogramming toward the glycolytic pathway (PMID 29491003)