CKAP5

cytoskeleton associated protein 5

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000175216
UniProt:
Q14008
OMIM:
611142
Synonyms:
CH-TOG, KIAA0097, TOG, TOGP

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-11.57) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal reti outer nuclear layer morphology, preweaning lethality, complete penetrance, abnormal embryo size, decreased body temperature, embryonic lethality prior to organogenesis

Subcellular localization

basal body, centrosome, cilia, cytosol, microtubules

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

CKAP5 has localized in basal body.