CKAP5

cytoskeleton associated protein 5

Ensembl:
ENSG00000175216
UniProt:
Q14008
OMIM:
611142
Synonyms:
CH-TOG, KIAA0097, TOG, TOGP

Cilia effects upon perturbation of CKAP5

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-11.57) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal reti outer nuclear layer morphology, preweaning lethality, complete penetrance, abnormal embryo size, decreased body temperature, embryonic lethality prior to organogenesis
Mouse ciliopathy phenotype:
abnormal embryo turning

Subcellular localization

basal body, centrosome, cilia, cytosol, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

CKAP5 has localized in basal body.

Model organism evidence

C. elegans (1 reference)

Microtubules (MTs) are cytoskeletal polymers that participate in diverse cellular functions, including cell division, intracellular trafficking, and templating of cilia and flagella.

PMIDs: 26985017