CKB

Cilia effects upon perturbation of CKB

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased prepulse inhibition, increased red blood cell distribution width, increased lymphocyte cell number, decreased brain weight, decreased mean platelet volume, decreased exploration in new environment, increased lean body mass, increased mean corpuscular hemoglobin, increased mean corpuscular volume, increased bone mineral content, abnormal vibrissa morphology, decreased total body fat amount

Mouse ciliopathy phenotype:

abnormal auditory brainstem response

Subcellular localization

cilia, cytosol

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Ckb and Ybx2 occurs at the axoneme of multi-cilia on the embryonic epithelium of Xenopus laevis(36508087).