CLCN4

chloride voltage-gated channel 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000073464
UniProt:
P51793
OMIM:
302910
Synonyms:
CLC-4, CLC4

Ciliogenesis screen results (5 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=766, lfc=0.69) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-6.52) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
X-linked non-syndromic intellectual disability

Subcellular localization

basal body, cilia

References: PMID:26546361

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Ion channel gene required for ciliogenesis.Mutations cause defects in cilia structure. Potential new candidate in human ciliopathies (26546361)