CLCN4

chloride voltage-gated channel 4

Ensembl:
ENSG00000073464
UniProt:
P51793
OMIM:
302910
Synonyms:
CLC-4, CLC4

Cilia effects upon perturbation of CLCN4

Ciliogenesis screen results (5 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=766, lfc=0.69) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-6.52) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
X-linked non-syndromic intellectual disability

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Ion channel gene required for ciliogenesis.Mutations cause defects in cilia structure. Potential new candidate in human ciliopathies (26546361)

Model organism evidence

Mus musculus (1 reference)

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

PMIDs: 26546361