CLDN2

claudin 2

Ensembl:: ENSG00000165376
UniProt:: P57739

Cilia effects upon perturbation of CLDN2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.82) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly

Function

Responsible for the + and H2O permeability of the tight junctions and despite being a ciliary protein, it is not necessary for ciliogenesis. Claudin-2 is associated to acetylated α-tubulin (22143774)

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