CLIP1

CAP-Gly domain containing linker protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000130779
UniProt:
P30622
OMIM:
179838
Synonyms:
CLIP, CLIP-170, CLIP170, CYLN1, RSN

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.70) PMID:41160700

Subcellular localization

centrosome, cytosol, flagella, microtubules

References: PMID:25613900

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CLIP1 has localized in flagella.