CLTC

clathrin heavy chain

Ensembl:
ENSG00000141367
UniProt:
Q00610
OMIM:
118955
Synonyms:
CLTCL2, HC

Cilia effects upon perturbation of CLTC

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.68) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=629, lfc=0.98) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
intellectual disability, autosomal dominant 56

Subcellular localization

cytosol, endosome, flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CLTC has localized in flagella.

Model organism evidence

C. elegans (1 reference)

elegans ciliary membrane transport.

PMIDs: 20980383