CNGA1

cyclic nucleotide gated channel subunit alpha 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000198515
UniProt:: P29973
OMIM:: 123825
Synonyms:: CNCG, CNCG1, CNG1, RCNC1, RCNCA, RP49

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.84) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.62) PMID:41160700

Phenotypes

Mouse phenotype:: decreased total reti thickness, abnormal reti outer nuclear layer morphology
Human ciliopathy phenotype:: retinitis pigmentosa; retinitis pigmentosa 49

Subcellular localization

cilia, ciliary tip

References: PMID:41005307, PMID:25319694

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

Subunit of the cyclic nucleotide-gated (Cng) channel localised to the outer segment. Mutations in Cnga1 which have been associated with retinitis pigmentosa in humans (25319694)

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