CNGA2

cyclic nucleotide gated channel subunit alpha 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000183862
UniProt:: Q16280
OMIM:: 300338
Synonyms:: CNCA, CNCA1, CNG2, FLJ46312, OCNC1, OCNCA, OCNCALPHA

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:17032767

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

Principal subunit of heteromeric olfactory CNG channels and homomeric CNGA2 channels in nonmotile cilia on olfactory sensory neurons (ORNs). N-terminus of CNGA2 are necessary for PIP3 regulation. In absence of CNGB1, it does assemble and form functional heteromeric channels in ORNs (17032767)

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