CNGA2

cyclic nucleotide gated channel subunit alpha 2

Ensembl:
ENSG00000183862
UniProt:
Q16280
OMIM:
300338
Synonyms:
CNCA, CNCA1, CNG2, FLJ46312, OCNC1

Cilia effects upon perturbation of CNGA2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Principal subunit of heteromeric olfactory CNG channels and homomeric CNGA2 channels in nonmotile cilia on olfactory sensory neurons (ORNs). N-terminus of CNGA2 are necessary for PIP3 regulation. In absence of CNGB1, it does assemble and form functio l heteromeric channels in ORNs (17032767)

Model organism evidence

C. elegans (3 references)

Notably, deactivating the cyclic nucleotide-gated (CNG) channel TAX-4 on the ciliary membrane promotes lifespan extension through a UPRER-dependent mechanism.

We demonstrate that ciliary localization of CNG channel subunits is interdependent on different channel subunits in specific cells, and identify sequences required for efficient ciliary targeting and localization of the TAX-2 CNGB and TAX-4 CNGA subunits.

PMIDs: 38857399, 23886944, 21124868

Mus musculus (1 reference)

The daf-25 dauer phenotype is suppressed by daf-10/IFT122 mutations (which disrupt ciliogenesis), but not by daf-6/PTCHD3 mutations (which prevent environmental exposure of sensory cilia), implying that DAF-25 functions in the cilia themselves.

PMIDs: 21124868