CNGA4

cyclic nucleotide gated channel subunit alpha 4

Ensembl:
ENSG00000132259
UniProt:
Q8IV77
OMIM:
609472
Synonyms:
CNCA2, CNG5, CNGB2, OCNC2, OCNCB

Cilia effects upon perturbation of CNGA4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Required for ciliary targeting of the olfactory CNG channel. Cooperation in mediating feedback modulation by Ca2+-CaM. In absence of CNGB1, it does assemble and form functio l heteromeric channels in olfactory sensory neurons (16980309)

Model organism evidence

C. elegans (4 references)

Notably, deactivating the cyclic nucleotide-gated (CNG) channel TAX-4 on the ciliary membrane promotes lifespan extension through a UPRER-dependent mechanism.

We demonstrate that ciliary localization of CNG channel subunits is interdependent on different channel subunits in specific cells, and identify sequences required for efficient ciliary targeting and localization of the TAX-2 CNGB and TAX-4 CNGA subunits.

PMIDs: 38857399, 23886944, 21124868, 16782012

Mus musculus (1 reference)

The daf-25 dauer phenotype is suppressed by daf-10/IFT122 mutations (which disrupt ciliogenesis), but not by daf-6/PTCHD3 mutations (which prevent environmental exposure of sensory cilia), implying that DAF-25 functions in the cilia themselves.

PMIDs: 21124868