CNGA4

cyclic nucleotide gated channel subunit alpha 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000132259
UniProt:: Q8IV77
OMIM:: 609472
Synonyms:: CNCA2, CNG5, CNGB2, OCNC2, OCNCB

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:16980309

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

Required for ciliary targeting of the olfactory CNG channel. Cooperation in mediating feedback modulation by Ca2+-CaM. In absence of CNGB1, it does assemble and form functional heteromeric channels in olfactory sensory neurons (16980309)

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