CNNM4

cyclin and CBS domain divalent metal cation transport mediator 4

Ensembl:
ENSG00000158158
UniProt:
Q6P4Q7
OMIM:
607805
Synonyms:
ACDP4, KIAA1592, SLC70A4

Cilia effects upon perturbation of CNNM4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Cone-Rod Dystrophy

Subcellular localization

flagella

Functional category

  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Cnnm4-deficient sperm are very similar to those of sperm lacking a functio l cation channel of sperm (CatSper) channel, which plays an essential role in Ca(2+) influx during sperm capacitation (27006114).