CNR1

cannabinoid receptor 1

Ensembl:
ENSG00000118432
UniProt:
P21554
OMIM:
114610
Synonyms:
CANN6, CB-R, CB1, CB1A, CB1K5

Cilia effects upon perturbation of CNR1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.94) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, decreased thigmotaxis, preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance, abnormal behavior, abnormal skin morphology, edema
Human ciliopathy phenotype:
obesity

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CB1 may be motile rather than primary cilia, as complex basal bodies and 9+2 ciliary structures (22791629).

Model organism evidence

Danio rerio (1 reference)

Previous reports have shown the presence of the key endocannabinoid receptor Cannabinoid receptor 1 (CB1 or Cnr1) in multiciliated (MCC) tissues and its upregulation in kidney diseases, yet the relationship between Cnr1 and renal MCC development is unknown.

PMIDs: 40558673