CNR1

cannabinoid receptor 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118432
UniProt:: P21554
OMIM:: 114610
Synonyms:: CANN6, CB-R, CB1, CB1A, CB1K5, CNR

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.94) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: hyperactivity, decreased thigmotaxis, preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance, abnormal behavior, abnormal skin morphology, edema
Human ciliopathy phenotype:: obesity

Subcellular localization

cilia

References: PMID:22791629

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

CB1 may be motile rather than primary cilia, as complex basal bodies and 9+2 ciliary structures (22791629).

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